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Fioricet (acetaminophen, butalbital, and caffeine) is used to treat tension headaches that are caused by muscle contractions.
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​Fioricet pills contain a combination of acetaminophen, butalbital, and caffeine. Acetaminophen is a pain reliever and fever reducer. Butalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache. Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

HOW FIORICET WORKS

Fioricet belongs to the class of medicines known as barbiturates because it contains butalbital. It may also be called a combination analgesic.

Experts aren't sure exactly how acetaminophen work, but suspect it may activate descending serotonergic inhibitory pathways in the CNS and other nociceptive pathways (nociceptive pain describes pain from physical or potential damage to the body such as that from a sports injury or dental procedure). Inhibition of the hypothalamic heat-regulating center gives acetaminophen its fever-lowering effect.

Caffeine is thought to enhance the pain-relieving effects of acetaminophen by up to 40%. In addition, it has vasoconstrictive properties, narrowing blood vessels in the brain thereby decreasing blood flow and oxygen tension (before a headache or a migraine, blood vessels tend to enlarge). This also helps to relieve pain.

Butalbital belongs to the class of medicines called barbiturates. When used for pain due to tension headaches experts believe it works by relaxing muscle contractions and causing sedation via an enhancement of the inhibitory effects of GABA (a neurotransmitter that regulates communication between brain cells).

BEFORE TAKING FIORICET​

Do not use Fioricet if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

You should not use Fioricet if you are allergic to it, if you have porphyria, or if you have recently used alcohol, sedatives, tranquilizers, or other opioids.

To make sure Fioricet is safe for you, tell your doctor if you have ever had:
  • stomach ulcer or bleeding;
  • kidney disease;
  • liver disease, cirrhosis, a history of alcoholism or drug addiction, or if you drink more than 3 alcoholic beverages per day;
  • a history of skin rash caused by any medication; or
  • a history of mental illness or suicidal thoughts.

FIORICET TIPS​

  • Do not drink more than two alcoholic drinks a day if you are a man or one alcoholic drink per day if you are a woman and taking Fioricet.
  • Talk to your doctor if you have any side effects of concern. Seek urgent medical advice if you develop an allergic-type reaction (difficulty breathing or swallowing, rash, or facial swelling) soon after taking Fioricet.
  • May be administered without regard to food; although food may decrease any reported stomach upset.
  • If you have been taking Fioricet regularly, or if you think you have become addicted to it, talk to your doctor about slowly withdrawing it, as sudden withdrawal may precipitate a withdrawal syndrome (symptoms include anxiety, dizziness, hallucinations, muscle twitching, nausea, seizures, sleeplessness, or tremor).
  • Fioricet can cause sedation and affect your ability to drive or operate machinery.
  • Do not overuse Fioricet because you may become addicted to it and have difficulty stopping it.
  • Over-use of Fioricet can also result in a medication-overuse headache (also known as a rebound headache) which occurs when analgesics are taken too frequently to relieve a headache. Do not take for more than 3 days each month.
  • Never share your Fioricet with anybody else.
  • Not recommended for women who are pregnant or breastfeeding.
  • Talk to your doctor or pharmacist before taking any other medications or natural products with Fioricet as it can interact with a large number of drugs.
  • Fioricet contains acetaminophen which may be "hidden" in other cough/cold medicines. The total dose of acetaminophen from any source should not exceed 4000mg per day (24 hours).

IMPORTANT INFORMATION

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